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Product info: Diabetes
Avandamet (METFORMIN + ROSIGLITAZONE) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes: Rosiglitazone maleate and metformin hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by increasing insulin sensitivity. Rosiglitazone improves glycemic control while reducing circulating insulin levels. Pharmacologic studies in animal models indicate that rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Rosiglitazone maleate is not chemically or functionally related to the sulfonylureas, the biguanides, or the α-glucosidase inhibitors.
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Important information about Avandamet
Do not use Avandamet if you have severe heart failure, kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Before taking Avandamet, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver disease, or eye problems caused by diabetes.
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Avandamet. Be sure the surgeon knows ahead of time that you are using Avandamet. Some people have developed a life-threatening condition called lactic acidosis while taking metformin. Get emergency medical help if you have any of these symptoms of lactic acidosis: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.
Before taking Avandamet
Do not use Avandamet if you have severe heart failure, kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Avandamet. Be sure the surgeon knows ahead of time that you are using this medication. Metformin may cause lactic acidosis (the build up of lactic acid in the body) that can start slowly and gradually get worse. Symptoms include muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Get emergency medical help if you have any of these symptoms of lactic acidosis, even if they are only mild. Early signs of lactic acidosis generally get worse over time and this condition can be fatal.
You may be more likely to develop lactic acidosis if you have liver disease, kidney disease, congestive heart failure, a serious infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk.
Before taking Avandamet, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver disease, or eye problems caused by diabetes.
Some women using Avandamet have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control. Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking Avandamet. Talk with your doctor if you are concerned about this possibility.
FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before you take Avandamet, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether metformin and rosiglitazone passes into breast milk or if it could harm a nursing baby. Do not take Avandamet without first talking to your doctor if you are breast-feeding a baby.
Taking certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with Avandamet.
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